In 2019 the academic team at the University of Glasgow published validation of PfCLK3 as a target with breakthrough potential in the treatment of malaria. Successful drug development would provide a single medicine that is curative, transmission blocking and prophylactic.
KELTICPharma Therapeutics was established to pursue targeting PfCLK3 using the transformative PEP-SMOL Drug Discovery Platform invented by the KELTICPharma Therapeutics Founders.
In addition to discovering novel hit matter in our malaria program the PEP-SMOL platform is being deployed by KELTICPharma Therapeutics to generate hit matter against ‘hard to target’ receptors with high clinical value.
The academic team based at the University of Glasgow together with the Business Team in Dublin have the combined innovation, deep target knowledge and corporate drug discovery expertise to deliver new receptor-based medicines and a novel anti-malarial treatment.
Generating next generation anti-malarials.
KELTICPharma Therapeutics founders have extensive experience in the malaria field particularly in the biochemical processes that are essential for parasite survival.
By identification of essential pathways the founders have established that a particular protein kinase called PfCLK3, when inhibited can not only kill the blood stage of the malaria parasite but also kill liver stage and prevent development through the sexual stages. In this way inhibitors to PfCLK3 can offer a cure, prophylaxis and a block of transmission.
The molecular parasitology and chemistry expertise with KELTICPharma Therapeutics and our collaborators are now pursing inhibition of PfCLK3 in a drug discovery program aimed at generating next generation anti-malarials.
Generating Receptor-Based Medicines
The Founders of KELTICPharma Therapeutics have decades of research experience in a class of cell surface receptor called G protein coupled receptors (GPCRs). This class of receptor are the worlds most successful drug targets. However despite this success the full potential of GPCRs as drug target has yet to be fully released.
A subclass of GPCRs have been classified as ‘hard to target’ due to the ligand binding pocket being shallow and poorly defined.
KELTICPharma Therapeutics a founders have invented a novel drug discovery platform called PEP-SMOL that is specifically designed to generate small drug-like molecule hits against shallow binding pockets.
By deploying PEP-SMOL – KELTICPharma Therapeutics will pursue drug discovery programs against high value GPCR targets that previously have been considered either ‘hard to target’ or even ‘un-druggable’.
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